Two editorials and one review addressing a wide range of topics related to cardiac electrophysiology and signaling have been published recently. In an editorial for the International Journal of Cardiology, we discuss the paper by Alhede et al. which identified that antiarrhythmic drugs are better than ablation at preventing atrial ectopy, whereas ablation is better at preventing recurrence of atrial fibrillation. These data suggest that there may be ‘benign’ (non-AF-inducing) and malignant (AF-inducing) premature atrial complexes and that antiarrhythmic drugs may not be able to prevent the malignant ones. In another editorial for Circulation Arrhythmia and Electrophysiology, we discuss the antiarrhythmic potential of small-conductance calcium-activated potassium (SK) channels. Finally, in a review for Laboratory Investigation, we provide an update on the regulation of G-proteins by nucleoside diphosphate kinases and caveolins. The full references are listed below and a complete overview of all publications can be found on the publications page:
Heijman J, Dobrev D, Crijns HJGM (2017). Targeting supraventricular ectopic
complexes: Which approach should be used and how does it affect atrial
fibrillation? Int J Cardiol. 244:202-203.
Heijman J, Dobrev D (2017). Inhibition of Small-Conductance Ca2+-Activated K+
Channels: The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial
Fibrillation? Circ Arrhythm Electrophysiol. 10(10). pii: e005776.
Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T (2017). Regulation of
heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update.
Lab Invest. Oct 16 Epub ahead of print.